Feeds

Boffins create super-muscular 'Hulk' mice: Humans next

You wouldn't like me when I'm squeaky

Intelligent flash storage arrays

Topflight biology brains say they have identified a key protein, the furtling of which could allow massively increased muscular development and strength in human beings. Genetic manipulation of the "Grb10" compound has already been tried out in mice, producing "hyper-muscular" rodents capable of almost super-murine feats.

"By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass," explains Dr Lowenna J Holt from the Garvan Institute of Medical Research in Australia. "Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes."

Grb10 is an "intracellular adaptor protein" which apparently acts by regulating down the level of insulin-like growth factor 1 (IGF1), the stuff which causes muscles to bulk up.

We learn:

Holt and her colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development. These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle.

The allied boffins go so far in their paper, to be published in print in September's FASEB Journal, as to describe the augmented Hulk-bulk mice as "hyper-muscular", hinting that especially sturdy cages may have been needed to contain the tiny but exceptionally buff rodents.

The scientists thus far are viewing potential Grb10 tweaking as a method for helping human patients to battle muscle wasting diseases, but there can be little doubt that the techniques - if successful - would also be abused by the bodybuilding and rogue-secret-military-special-operations-organisation communities - and indeed perhaps by the time-poor or lazy. ®

Choosing a cloud hosting partner with confidence

More from The Register

next story
SECRET U.S. 'SPACE WARPLANE' set to return from SPY MISSION
Robot minishuttle X-37B returns after almost 2 years in orbit
LOHAN crash lands on CNN
Overflies Die Welt en route to lively US news vid
'Utter killjoy Reg hacks have NEVER BEEN LAID', writes a fan
'Shuddit, smarty pants!' Some readers reacted badly to our last Doctor Who review ...
Experts brand LOHAN's squeaky-clean box
Phytosanitary treatment renders Vulture 2 crate fit for export
Carry On Cosmonaut: Willful Child is a poor taste Star Trek parody
Cringeworthy, crude and crass jokes abound in Steven Erikson’s sci-fi debut
White LED lies: It's great, but Nobel physics prize-winning great?
How artificial lighting could offer an artificial promise
Origins of SEXUAL INTERCOURSE fished out of SCOTTISH LAKE
Fossil find proves it first happened 385 million years ago
prev story

Whitepapers

Forging a new future with identity relationship management
Learn about ForgeRock's next generation IRM platform and how it is designed to empower CEOS's and enterprises to engage with consumers.
Why cloud backup?
Combining the latest advancements in disk-based backup with secure, integrated, cloud technologies offer organizations fast and assured recovery of their critical enterprise data.
Win a year’s supply of chocolate
There is no techie angle to this competition so we're not going to pretend there is, but everyone loves chocolate so who cares.
High Performance for All
While HPC is not new, it has traditionally been seen as a specialist area – is it now geared up to meet more mainstream requirements?
Intelligent flash storage arrays
Tegile Intelligent Storage Arrays with IntelliFlash helps IT boost storage utilization and effciency while delivering unmatched storage savings and performance.