Feeds

Boffins create super-muscular 'Hulk' mice: Humans next

You wouldn't like me when I'm squeaky

SANS - Survey on application security programs

Topflight biology brains say they have identified a key protein, the furtling of which could allow massively increased muscular development and strength in human beings. Genetic manipulation of the "Grb10" compound has already been tried out in mice, producing "hyper-muscular" rodents capable of almost super-murine feats.

"By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass," explains Dr Lowenna J Holt from the Garvan Institute of Medical Research in Australia. "Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes."

Grb10 is an "intracellular adaptor protein" which apparently acts by regulating down the level of insulin-like growth factor 1 (IGF1), the stuff which causes muscles to bulk up.

We learn:

Holt and her colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development. These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle.

The allied boffins go so far in their paper, to be published in print in September's FASEB Journal, as to describe the augmented Hulk-bulk mice as "hyper-muscular", hinting that especially sturdy cages may have been needed to contain the tiny but exceptionally buff rodents.

The scientists thus far are viewing potential Grb10 tweaking as a method for helping human patients to battle muscle wasting diseases, but there can be little doubt that the techniques - if successful - would also be abused by the bodybuilding and rogue-secret-military-special-operations-organisation communities - and indeed perhaps by the time-poor or lazy. ®

3 Big data security analytics techniques

More from The Register

next story
So, just how do you say 'the mutt's nuts' in French?
Vital linguistic question interrupts LOHAN spaceplane mission
95 floors in 43 SECONDS: Hitachi's new ultra-high-speed lift
Guangzhou skyscraper denizens to hold on to hats
Most Americans doubt Big Bang, not too sure about evolution, climate change – survey
Science no match for religion, politics, business interests
KILLER SPONGES menacing California coastline
Surfers are safe, crustaceans less so
Discovery time for 200m WONDER MATERIALS shaved from 4 MILLENNIA... to 4 years
Alloy, Alloy: Boffins in speed-classification breakthrough
LOHAN and the amazing technicolor spaceplane
Our Vulture 2 livery is wrapped, and it's les noix du mutt
Liftoff! SpaceX Falcon 9 lifts Dragon on third resupply mission to ISS
SpaceX snaps smartly into one-second launch window
STEALTHY NANOROBOTS dress up as viruses, prepare to sneak into YOUR BODY
Cloaking techniques nicked from viruses tackle roadblocks on way to medical frontier
prev story

Whitepapers

Mobile application security study
Download this report to see the alarming realities regarding the sheer number of applications vulnerable to attack, as well as the most common and easily addressable vulnerability errors.
3 Big data security analytics techniques
Applying these Big Data security analytics techniques can help you make your business safer by detecting attacks early, before significant damage is done.
The benefits of software based PBX
Why you should break free from your proprietary PBX and how to leverage your existing server hardware.
Securing web applications made simple and scalable
In this whitepaper learn how automated security testing can provide a simple and scalable way to protect your web applications.
Combat fraud and increase customer satisfaction
Based on their experience using HP ArcSight Enterprise Security Manager for IT security operations, Finansbank moved to HP ArcSight ESM for fraud management.