Feeds

Magnetic medicines hit the cancerous spot

Boffins develop iron core for anti-cancer drug, drag it to tumours with magnets

Boost IT visibility and business value

A team of researchers in Australia and Scotland has designed an iron core for the anti-cancer drug Cisplatin, so that it can be dragged by magnets to wherever in your body it can do its best work.

The team’s work is detailed in a new paper,Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields, in the journal Inorganica Chimica Acta. The paper details how “The platinum-based chemotherapeutic drug cisplatin is highly effective in the treatment of solid tumours, but its use is restricted by poor bioavailability, severe dose-limiting side effects and rapid development of drug resistance.”

To overcome those issues, the team “tethered the active component of cisplatin to gold-coated iron oxide nanoparticles to improve its delivery to tumours and increase its efficacy. Iron oxide nanoparticles (FeNPs) were synthesised via a co-precipitation method before gold was reduced onto its surface.” That process had the effect of making the drug sufficiently magnetic that “external magnets were used to demonstrate that the nanoparticles could be accumulated in specific regions and that cell growth inhibition was localised to those areas.”

Magnetic medicine

Magnetic medicines in action

Dr Nial White, a Senior Lecturer from the University of Sydney’s Faculty of Pharmacy, likened the process to the student experiment of using a magnet to drag iron filings into patterns.

"When we take regular medication it is difficult to manage where it goes,” Dr White explained. “But this discovery means we can potentially direct exactly where in the human body a drug goes. We can move it to the desired cancer tumour site using powerful magnetic fields. Otherwise, a strong magnet could be implanted into a tumour, and draw the drug into the cancer cells that way."

Dr White says this approach to drug delivery has the potential benefit of concentrating medicines in the tissues that need help.

"Many of the side-effects associated with chemotherapy occur because the drugs spread throughout the body, killing healthy organs as well as cancers,” he says."Ultimately, this technology could greatly reduce or even eliminate the severe side-effects that people associate with chemotherapy such as hair loss, nausea, vomiting, low red blood cells and an increased risk of infection." ®

Gartner critical capabilities for enterprise endpoint backup

More from The Register

next story
LOHAN packs bags for SPACEPORT AMERICA!
Spanish launch goes titsup, we're off to the US of A
Gigantic toothless 'DRAGONS' dominated Earth's early skies
Gummy pterosaurs outlived toothy competitors
'Leccy racer whacks petrols in Oz race
ELMOFO rakes in two wins in sanctioned race
TRANSMUTATION claims US LENR company
Ten points of stuff out of a five pound bag
Boffins ID freakish spine-smothered prehistoric critter: The CLAW gave it away
Bizarre-looking creature actually related to velvet worms
CRR-CRRRK, beep, beep: Mars space truck backs out of slippery sand trap
Curiosity finds new drilling target after course correction
BAT-GOBBLING urban SPIDER QUEENS swell to ENORMOUS SIZE
But they'd lose a deathmatch against the coming Humvee-sized, armoured Arctic ones
Astronomers scramble for obs on new comet
Amateur gets fifth confirmed discovery
prev story

Whitepapers

Implementing global e-invoicing with guaranteed legal certainty
Explaining the role local tax compliance plays in successful supply chain management and e-business and how leading global brands are addressing this.
7 Elements of Radically Simple OS Migration
Avoid the typical headaches of OS migration during your next project by learning about 7 elements of radically simple OS migration.
BYOD's dark side: Data protection
An endpoint data protection solution that adds value to the user and the organization so it can protect itself from data loss as well as leverage corporate data.
Consolidation: The Foundation for IT Business Transformation
In this whitepaper learn how effective consolidation of IT and business resources can enable multiple, meaningful business benefits.
High Performance for All
While HPC is not new, it has traditionally been seen as a specialist area – is it now geared up to meet more mainstream requirements?