Feeds

‘Pitstops’ can inhibit viruses

Boffins propose new idea for blocking HIV, cancer

A new approach to endpoint data protection

A compound dubbed the “pitstop” has been proposed as offering a new way to defend the body against invaders such as viruses and cancers.

The joint Australian-German project is looking at cell signalling behaviours as offering the chance to block diseases that work by invading human cells.

Cell membranes have to keep nasties out, but have to be able to let nutrients in – and it is the nutrient pathway that provides the gap in defences exploited by attackers. The opening for nutrients is provided by signalling molecules, and it’s the behaviour of those signaling molecules that has attracted the attention of Professor Phil Robinson of the Children’s Medical Research Institute in Sydney, German scientists Volker Haucke of Berlin’s Freie Universität, Adam McCluskey of the University of Newcastle, and their collaborators.

A process called clathrin-mediated endocytosis (CME) regulates operations such as nutrient absorption in cells. To invade cells, viruses and other pathogens hijack the clathrin that cells use to take in nutrients, invade the cell, and then use the cells' mechanisms to replicate their own genetic material throughout the body.

The researchers say they have developed “pitstop” compounds that interfere with the absorption of pathogens such as HIV, and say that if treatments can be developed based on these “pitsops”, they could block a wide range of invaders.

“What we’ve found is a way to tackle infectious diseases and viral infections; not all of them but probably a large chunk of them,” Professor Robinson told AAP.

Defending clathrin against hijacking, Robinson says, offers a way to prevent pathogens invading the cells, rather than fighting infection after it takes place. He says the compounds that the researchers have used are simple, offering “breathtaking” scope for improvement.

The next step for the researchers will be to find out whether or not their “pitstop” compounds are safe for humans.

The abstract of their research, published in the journal Cell, is here. ®

The Essential Guide to IT Transformation

More from The Register

next story
Just TWO climate committee MPs contradict IPCC: The two with SCIENCE degrees
'Greenhouse effect is real, but as for the rest of it ...'
Asteroid's DINO KILLING SPREE just bad luck – boffins
Sauricide WASN'T inevitable, reckon scientists
Brit amateur payload set to complete full circle around PLANET EARTH
Ultralight solar radio tracker in glorious 25,000km almost-space odyssey
Boffins spot weirder quantum capers as neutrons take the high road, spin takes the low
Cheshire cat effect see neutrons and their properties walk different paths
NASA Mars rover FINALLY equals 1973 Soviet benchmark
Yet to surpass ancient Greek one, however
Famous 'Dish' radio telescope to be emptied in budget crisis: CSIRO
Radio astronomy suffering to protect Square Kilometre Array
prev story

Whitepapers

7 Elements of Radically Simple OS Migration
Avoid the typical headaches of OS migration during your next project by learning about 7 elements of radically simple OS migration.
Implementing global e-invoicing with guaranteed legal certainty
Explaining the role local tax compliance plays in successful supply chain management and e-business and how leading global brands are addressing this.
Consolidation: The Foundation for IT Business Transformation
In this whitepaper learn how effective consolidation of IT and business resources can enable multiple, meaningful business benefits.
Solving today's distributed Big Data backup challenges
Enable IT efficiency and allow a firm to access and reuse corporate information for competitive advantage, ultimately changing business outcomes.
A new approach to endpoint data protection
What is the best way to ensure comprehensive visibility, management, and control of information on both company-owned and employee-owned devices?