Feeds

Nano cancer-bombs and mini organs from MIT

Honey, I shrunk my liver...

Build a business case: developing custom apps

Scientists at MIT have developed remote-controlled nano particles that, with the push of a button, can deliver drugs directly to a tumour. The same research director has also found a way to build tiny human "livers" just 500 micrometres across. This work should lead to more reliable toxicity testing for new drugs.

According to Geoff von Maltzahn, post-doctoral researcher at the Harvard-MIT division of health sciences & technology (HST), the nano particles are first persuaded to clump together, which makes it easier to track their progress through a patient's body. Then, drug molecules are attached to the clumps of nanoparticles with DNA tethers and the whole lot is injected into the patient.

The nanoparticles are then tracked with an MRI scanner (hence the clumping). When they get to their target they are pulsed with an electromagnetic field at between 350-400kHz. This is harmless to the human body, but melts the tether and releases the drugs exactly where they are needed.

The breakthrough rests on a property of the nanoparticles: superparamagnetism. This characteristic causes them to give off heat when they are exposed to a magnetic field. This heat breaks the connection with the DNA tether, and allows the system to deliver the drugs.

Using DNA as the tether has another advantage: it makes it possible to choose the EM frequency that will break the bond, since longer or differently arranged strands will have different melting points. This means one clump of nanoparticles can carry multiple doses of drugs to several sites. If each drug has differently tuned DNA tethers, doctors can use a different EM frequency to deliver each dose.

The work is reported in the 15 November online issue of Advanced Materials. Lead author Dr Sangeeta Bhatia, an associate professor in the HST, says it could lead to the improved diagnosis and targeted treatment of cancer.

Bhatia and her researchers have also developed miniature livers which could pave the way for safer and more reliable drug toxicity testing. Much of current testing is done on liver cells from rats, which don't always respond the way human livers do, or on dying human cells, which might only survive for a few days in a lab.

HST postdoctoral associate Salman Khetani describes the work in a paper published in the 18 November online issue of Nature Biotechnology. Khetani used micropatterning technology (as with building a chip) to arrange the liver cells into colonies just 500 micrometres across.

The tiny clusters of cells behave much like real livers - they secrete the blood protein albumin, synthesise urea, and produce enzymes that break down drugs and toxins. The mini livers can also survive for up to six weeks, the researchers report. ®

Secure remote control for conventional and virtual desktops

More from The Register

next story
Boffins attempt to prove the UNIVERSE IS JUST A HOLOGRAM
Is this the real life? Is this just fantasy?
Our LOHAN spaceplane ballocket Kickstarter climbs through £8000
Through 25 per cent but more is needed: Get your UNIQUE rewards!
China building SUPERSONIC SUBMARINE that travels in a BUBBLE
Shanghai to San Fran in two hours would be a trick, though
LOHAN tunes into ultra long range radio
And verily, Vultures shall speak status unto distant receivers
SpaceX prototype rocket EXPLODES over Texas. 'Tricky' biz, says Elon Musk
No injuries or near injuries. Flight stayed in designated area
Galileo, Galileo! Galileo, Galileo! Galileo fit to go. Magnifico
I'm just a poor boy, nobody loves me. But at least I can find my way with ESA GPS by 2017
EOS, Lockheed to track space junk from Oz
WA facility gets laser-eyes out of the fog
prev story

Whitepapers

Top 10 endpoint backup mistakes
Avoid the ten endpoint backup mistakes to ensure that your critical corporate data is protected and end user productivity is improved.
Implementing global e-invoicing with guaranteed legal certainty
Explaining the role local tax compliance plays in successful supply chain management and e-business and how leading global brands are addressing this.
Backing up distributed data
Eliminating the redundant use of bandwidth and storage capacity and application consolidation in the modern data center.
The essential guide to IT transformation
ServiceNow discusses three IT transformations that can help CIOs automate IT services to transform IT and the enterprise
Next gen security for virtualised datacentres
Legacy security solutions are inefficient due to the architectural differences between physical and virtual environments.